Biomarkers Predicting Treatment-Response in Nephrotic Syndrome of Children: A Systematic Review
10.3339/jkspn.2021.25.2.92
- Author:
Jiwon M. LEE
1
;
Yo Han AHN
;
Seon Hee LIM
;
Hee Gyung KANG
Author Information
1. Division of Rare Disease Management, Bureau of Chronic Disease Management, Korea Disease Control and Prevention Agency, Osong, Korea
- Publication Type:1
- From:Childhood Kidney Diseases
2021;25(2):92-111
- CountryRepublic of Korea
- Language:English
-
Abstract:
Purpose:Nephrotic syndrome (NS) is the most common form of glomerulopathy in children. Most pediatric patients respond to glucocorticosteroid treatment (steroid-sensitive NS, SSNS), while approximately 10–15% will remain unresponsive or later become steroid-resistant. There has been a long-standing effort to find biomarkers that may predict steroid responsiveness.
Methods:We systematically reviewed current studies which investigated clinically relevant biomarkers for predicting steroid responsiveness in pediatric NS. We performed a PubMed and EMBASE search to identify eligible articles. We collected data on urinary markers, blood/serum markers (including cellular phenotypes and mRNA expression), genotypes and HLA allele frequency.
Results:A total of 659 articles were identified following electronic and manual searches. After reviewing the titles, abstracts, and full texts, 72 eligible articles were finally included. Vitamin D-binding protein (VDBP) seemed to be significantly elevated in SRNS than in SSNS, in both serum and urine specimen, although further validation is required.
Conclusions:The present paper narratively illustrates current understandings of potential biomarkers that may help predict steroid responsiveness. Further investigation and collaboration involving a larger number of patients are necessary.
