Influence of endotoxin induced fever on the pharmacokinetics of intramuscularly administered cefepime in rabbits.
- Author:
Ayman GOUDAH
1
;
Samar M MOUNEIR
;
Jae Han SHIM
;
A M EL-ATY
Author Information
- Publication Type:Original Article
- Keywords: cefepime; microbiological assay; pharmacokinetics; rabbits
- MeSH: Animals; Anti-Bacterial Agents/*administration&dosage/blood/*pharmacokinetics; Area Under Curve; Cephalosporins/*administration&dosage/blood/*pharmacokinetics; Endotoxins/pharmacology; Escherichia coli Infections/drug therapy/physiopathology; Fever/chemically induced/*physiopathology; Half-Life; Injections, Intramuscular; Male; Rabbits
- From:Journal of Veterinary Science 2006;7(2):151-155
- CountryRepublic of Korea
- Language:English
- Abstract: This study examined the effect of experimentally induced fever on the pharmacokinetics of cefepime (75 mg/kg BW) administered intramuscularly to six rabbits. The study was carried out in two consecutive phases separated by a two-week washout period. An infection was induced by an intravenous inoculation of 5 x 10(8) colony-forming units of Escherichia coli 24 h before the pharmacokinetic investigation. A quantitative microbiological assay was employed to measure the plasma cefepime concentrations using an agar-gel diffusion method with Bacillus subtilis ATCC 6633 as the test organism. Twenty-four hour after the injection, the rectal temperature in the infected animals increased by 1degrees C. There was a significant reduction in the elimination halflife by 21.8% in the febrile rabbits compared to healthy animals. In addition, the infection significantly increased the peak plasma concentrations by 11.9%, the mean residence time by 19.9%, the area under the plasmaconcentration- time curve by 53.6% and the area under the moment curve by 62.3%. In conclusion, the endotoxin-induced febrile state produced significant changes in the plasma levels as well as some of the pharmacokinetic variables of cefepime in rabbits.
