Intracranial Tumors Associated With IgG4-Related Disease
- Author:
Dongkyu KIM
1
;
Se Hoon KIM
;
Eui Hyun KIM
Author Information
- Publication Type:CASE REPORT
- From:Brain Tumor Research and Treatment 2021;9(2):93-99
- CountryRepublic of Korea
- Language:English
- Abstract: IgG4-related disease (IgG4-RD) is an immune-mediated inflammatory condition which is characterized by dense lymphoplasmacytic infiltrations with a predominance of IgG4 plasma cells in the affected tissue. Although pachymeninx and pituitary gland are the most common sites where IgG4-RD infiltrates, the associations with IgG4-RD and a true intracranial tumor have not been yet reported in literature. Herein, we report two cases with intracranial tumors associated with IgG4-RD; a 36-year-old male patient with a huge meningioma and another 54-year old woman with a pituitary macroadenoma. Pathological examination revealed their tumors were substantially infiltrated by IgG4 plasma cells indicating its possible relation with IgG4-RD.
