Systematic Review of Recent Lipidomics Approaches Toward Inflammatory Bowel Disease
10.4062/biomolther.2021.125
- Author:
Eun Goo LEE
1
;
Young Cheol YOON
;
Jihyun YOON
;
Seul Ji LEE
;
Yu-Kyoung OH
;
Sung Won KWON
Author Information
1. College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea
- Publication Type:Review
- From:Biomolecules & Therapeutics
2021;29(6):582-595
- CountryRepublic of Korea
- Language:English
-
Abstract:
Researchers have endeavored to identify the etiology of inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis. Though the pathogenesis of inflammatory bowel diseases remains unknown, dysregulation of the immune system in the host gastrointestinal tract is believed to be the major causative factor. Omics is a powerful methodological tool that can reveal biochemical information stored in clinical samples. Lipidomics is a subset of omics that explores the lipid classes associated with inflammation. One objective of the present systematic review was to facilitate the identification of biochemical targets for use in future lipidomic studies on inflammatory bowel diseases. The use of high-resolution mass spectrometry to observe alterations in global lipidomics might help elucidate the immunoregulatory mechanisms involved in inflammatory bowel diseases and discover novel biomarkers for them. Assessment of the characteristics of previous clinical trials on inflammatory bowel diseases could help researchers design and establish patient selection and analytical method criteria for future studies on these conditions. In this study, we curated literature exclusively from four databases and extracted lipidomics-related data from literature, considering criteria. This paper suggests that the lipidomics approach toward research in inflammatory bowel diseases can clarify their pathogenesis and identify clinically valuable biomarkers to predict and monitor their progression.
