A case of diacerein-induced DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome with thromboembolic complications
10.4168/aard.2020.8.3.150
- Author:
Hyo-In RHYOU
1
;
Soo-Jung UM
;
Mee Sook ROH
;
Young-Hee NAM
Author Information
1. Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea
- Publication Type:CASE REPORT
- From:Allergy, Asthma & Respiratory Disease
2020;8(3):150-154
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Diacerein is a safe drug for osteoarthritis due to its inhibitory effect on proinflammatory cytokines. Its common side effects, such as diarrhea, abdominal pain and skin rash, are relatively mild. There have been a few cases of drug reactions with eosinophilia and systemic symptoms (DRESS) syndrome accompanied by thromboembolic complications. We report the first case of diacerein-induced DRESS syndrome with thromboembolic complications. A 64-year-old man developed fever, skin rash, increase in liver enzymes, eosinophilia, deep vein thrombosis (DVT) and pulmonary thromboembolism (PTE) after taking diacerein. DVT and PTE were improved after anticoagulation therapy; however, fever, skin rash, eosinophilia and increase in liver enzymes were aggravated. A high-dose systemic corticosteroid (methylprednisolone 1 mg/kg/day) was administered, after which his clinical conditions improved.
