Recent advances in neonatal Fc receptor targeted drug delivery systems
10.16438/j.0513-4870.2021-1636
- VernacularTitle:作用于新生儿Fc受体药物递送系统研究进展
- Author:
Miao HE
1
,
2
,
3
;
Bao-wei PENG
3
,
4
;
Yu-hong XU
3
,
4
Author Information
1. School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China
2. College of Pharmacy, Dali University, Dali 671000, China
3. Innovative Research Team of Precision and Targeted Drug Delivery of Yunnan Province, Dali 671000, China
4. College of Pharmacy, Dali University, Dali 671000, China
- Publication Type:Research Article
- Keywords:
neonatal Fc receptor;
rug delivery system;
protein engineering;
pharmacokinetics;
therapy
- From:
Acta Pharmaceutica Sinica
2022;57(1):159-168
- CountryChina
- Language:Chinese
-
Abstract:
The neonatal Fc receptor (FcRn) was first found to be a membrane protein that maternal antibodies transmitted to fetuses and newborns, and also expressed in multiple organs and tissues for whole life in adults. It plays a significant role to central regulate the lifespan of immunoglobulin G and serum albumin, as well as its involvement in innate and adaptive immune responses. In modern biopharmaceuticals, FcRn is a great potential drug delivery target and a highlighted subject for current research. This paper briefly describes the basic biological properties and action mechanism of FcRn, as well as the commonly used drug carrier design strategies of FcRn, especially the functional applications of prolonging half-life, targeted drug delivery, transmembrane and antigen presentation and so on. We propose that these distribution in different tissues and the diverse biological activities may have significant implications of targeting FcRn for novel drug delivery systems and immunotherapy.
