Research progress of exosomes based targeted delivery of antitumor drugs
10.16438/j.0513-4870.2021-1354
- VernacularTitle:基于外泌体的抗肿瘤药物靶向递送的研究进展
- Author:
Hao-nan XING
1
;
Mei LU
2
;
Ying-qi LIU
1
;
Yu-han DONG
1
;
Ai-ping ZHENG
1
Author Information
1. Institute of Pharmacology and Toxicology, Academy of Military Medicine, Beijing 100850, China
2. Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology, Beijing 100081, China
- Publication Type:Research Article
- Keywords:
neoplasm;
exosome;
rug delivery system;
antineoplastic agent;
genetic engineering
- From:
Acta Pharmaceutica Sinica
2022;57(1):150-158
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are one of the most important ways of cell-to-cell communication in living lives. They are involved in major physiological and pathological processes, including drug resistance, infection propagation, cancer development and cardiovascular diseases. The biological functions of exosomes made it possess characteristics of low immunogenicity, high delivery efficiency, ability to cross multiple biological barriers and targeting capacity, which also encourage people to try to use it as a drug carrier to overcome the disadvantages of poor stability, low solubility, low bioavailability and high toxicity of some drugs. In this paper, the latest progress of exosomes in the delivery of antitumor drugs, including small chemotherapeutic drugs, biological macromolecules and nucleic acid drugs, is reviewed. In addition, the isolation, drug loading, and modification method and the application prospect of exosomes are also discussed.
