Research advances on antitumor mechanism of NK cells and its application in cancer targeted therapy

VernacularTitle:NK细胞的抗肿瘤机制及其在肿瘤靶向治疗中的应用研究进展
Author: Shu-fen ZHANG ; Ying-ping ZENG ; Ting-ting MENG ; Hong YUAN ; Fu-qiang HU
Publication Type:Research Article
Keywords: natural killer cell; cancer immunotherapy; cancer targeting; biomimetic nanoparticle; rug delivery
From: Acta Pharmaceutica Sinica 2022;57(1):122-133
CountryChina
Language:Chinese
Abstract: Natural killer (NK) cells, as an essential part of innate immunity, can directly identify and kill tumor cells after being activated by the synergistic action of surface inhibitory receptors and activated receptors. It can secrete cytokines to recruit dendritic cells (DCs), induce DCs maturation and enhance adaptive immune response. It can target cancer stem cells (CSCs) and circulating tumor cells (CTCs) to inhibit cancer metastasis. NK cells have a unique inflammatory tendency, which can respond to cytokines and chemokines released from tumor sites and migrate to tumor sites, making them occupy an important advantage in cancer targeted therapy. The research on cancer targeted therapy of NK cells as drug delivery carriers, NK cell membrane-coated biomimetic nanoparticles, and NK cell extracellular vesicles (NKEVs) has attracted more and more attention. The article will focus on the mechanism of NK cells inhibiting cancer, and summarize the research progress of cancer targeted therapy of NK cells.