Diagnostic value of transient elastography in the staging of hepatic fibrosis in patients with autoimmune liver disease: A Meta-analysis
10.3969/j.issn.1001-5256.2022.01.015
- VernacularTitle:瞬时弹性成像技术对自身免疫性肝病肝纤维化分期诊断价值的Meta分析
- Author:
Zhiran YANG
1
;
Linheng WANG
2
;
Yuan LI
1
;
Fusheng LIU
3
;
Yu WANG
1
;
Jianfang WANG
2
;
Runhua CHEN
2
Author Information
1. The Second Clinical Medical College of Beijing University of Chinese Medicine, Beijing 100029, China
2. Department of Spleen-stomach, Liver-gallbladder, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China
3. Emergency Department, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China
- Publication Type:Original Articles_Liver Fibrosis and Liver Cirrhosis
- Keywords:
Liver Cirrhosis;
Autoimmune Diseases;
Elasticity Imaging Techniques;
Meta-Analysis as Topic
- From:
Journal of Clinical Hepatology
2022;38(1):97-103
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of transient elastography (TE) in the staging of hepatic fibrosis in patients with autoimmune liver disease (ALD). Methods PubMed, Embase, the Cochrane Library, CNKI, Wanfang Data, and VIP databases were searched for English and Chinese articles on TE in the staging of hepatic fibrosis in ALD published from January 2000 to January 2021. Two reviewers independently performed data extraction for the articles included, and QUADAS2 was used for quality assessment. The bivariate mixed effects model in Stata 15.0 software was used to perform the Meta-analysis. Results A total of 11 articles were included, with 1041 patients in total. In the diagnosis of significant hepatic fibrosis (F≥2), TE had a pooled sensitivity of 0.81 (95% CI : 0.75-0.86), a specificity of 0.87(95% CI 0.79-0.92), and an area under the receiver operating characteristic curve (AUC) of 0.91(95% CI 0.88-0.93); in the diagnosis of advanced hepatic fibrosis (F≥3), TE had a pooled sensitivity of 0.81(95% CI 0.74-0.87), a sensitivity of 0.90(95% CI 0.85-0.93), and an AUC of 0.92(95% CI 0.90-0.94); in the diagnosis of early-stage liver cirrhosis (F4), TE had a pooled sensitivity of 0.87(95% CI 0.74-0.93), a specificity of 0.93(95% CI 0.87-0.97), and an AUC of 0.96(95% CI 0.94-0.97). Conclusion TE has a good diagnostic value in evaluating significant liver fibrosis, advanced liver fibrosis, and early-stage liver cirrhosis in patients with ALD, especially with a relatively high diagnostic accuracy for early-stage liver cirrhosis.
