Research advances in targeting autophagy to alleviate hepatic ischemia-reperfusion injury
10.3969/j.issn.1001-5256.2022.01.037
- VernacularTitle:靶向自噬缓解肝缺血再灌注损伤的研究进展
- Author:
Zhen LI
1
;
Ke WANG
1
;
Kaiqiang WANG
1
;
Kexian YU
2
Author Information
1. Graduate School of Qinghai University, Xining 810016, China
2. School of Traditional Chinese Medicine, Medical College of Qinghai University, Xining 810016, China
- Publication Type:Reviews
- Keywords:
Autophagy;
Reperfusion Injury;
Oxidative Stress
- From:
Journal of Clinical Hepatology
2022;38(1):210-214
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic ischemia-reperfusion injury (HIRI) is a common clinical problem after hepatectomy and liver transplantation and is the main cause of liver dysfunction and liver failure after transplantation. In recent years, autophagy-mediated pathways have become a research hotspot in alleviating HIRI. Autophagy refers to the process in which a large number of substrates such as cytoplasm and damaged organelles are transported into lysosomes for digestion and degradation, so as to constantly renew, reshape, and reuse cells. This article summarizes the research advances in the mechanism of targeting autophagy to alleviate HIRI from the aspects of gene, protein, signaling pathway, inflammatory response, oxidative stress, and mitochondrial and endoplasmic reticulum stress, as well as existing problems and prospects in research, in order to provide theoretical support for the future research on alleviating HIRI by targeting autophagy.
