Association between intrahepatic bile duct alterations and liver fibrosis
10.3969/j.issn.1001-5256.2022.01.032
- VernacularTitle:肝内胆管改变与肝纤维化的关系
- Author:
Wenzheng YOU
1
;
Wanlei REN
2
;
Shiying XUAN
1
;
Doudou HU
1
,
3
Author Information
1. Qingdao Clinical Medical College Affiliated to Nanjing Medical University, Qingdao, Shandong 266011, China
2. First Department of Traditional Chinese Medicine, Qingdao Central Hospital Affiliated to Qingdao University, Qingdao, Shandong 266042, China
3. Second Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, Shandong 266011, China
- Publication Type:Reviews
- Keywords:
Liver Cirrhosis;
Bile Ducts, Intrahepatic;
Pathologic Processes
- From:
Journal of Clinical Hepatology
2022;38(1):187-190
- CountryChina
- Language:Chinese
-
Abstract:
Liver cirrhosis is a liver disease caused by various factors and is characterized by diffuse fibrous hyperplasia, lobular structural damage, and pseudolobule formation. Bile duct proliferation has been observed in a variety of animal models of liver cirrhosis and patients with liver cirrhosis caused by different etiologies, and it is regulated by signaling pathways with the involvement of multiple regulatory factors such as neuropeptides, neurotransmitters, and hormones. Moreover, the proliferated bile ducts promote the formation of liver fibrosis by mediating the proliferation and activation of hepatic stellate cells. This article summarizes the changes of the intrahepatic bile duct system in liver cirrhosis and its influence on the process of liver fibrosis, various signaling pathways associated with cholangiocyte proliferation and liver fibrosis, and the value of the dynamic evolution of bile duct structure in predicting the degree of liver fibrosis. It is pointed out that bile duct proliferation may become a potential target for the intervention of liver fibrosis, which provides new ideas and methods for early treatment and reversal of liver fibrosis.
