Research progress of receptor ，pathway and pharmacological effect of 3-iodothyronine
- VernacularTitle:3-碘甲状腺原氨酸的受体、通路及药理学效应研究进展
- Author:
Lili MO
1
,
2
;
Changchao ZOU
3
;
Qili XU
1
,
2
;
Bo WEI
1
;
Wei LI
1
,
2
;
Anning ZENG
4
;
Zhangrong CHEN
1
;
Xingde LIU
3
;
Haiyan ZHOU
1
Author Information
1. Dept. of Cardiology，the Affiliated Hospital of Guizhou Medical University，Guiyang 550004，China
2. School of Clinical Medicine，Guizhou Medical University，Guiyang 550004，China
3. Dept. of Cardiology，the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine，Guiyang 550004，China
4. Dept. of Cardiology，Qiannan Buyi and Miao Autonomous Prefecture People’s Hospital，Guizhou Duyun 558000，China
- Publication Type:Journal Article
- Keywords:
3-iodothyronamine;
receptor;
signal pathway;
pharmacological effect
- From:
China Pharmacy
2022;33(2):244-250
- CountryChina
- Language:Chinese
-
Abstract:
3-iodothyronamine（T1AM）is an endog enous derivative of thyroid hormone. It can also be used as exogenous drug. It can play pharmacological effects such as reducing cardiac output and coronary flow ，slowing heart rate ，promoting lipolysis ， reducing basic metabolism and improving learning and memory ability. Its regulatory effect on metabolism is similar to that of thyroxine，but regulatory effect on heart and thermogenic function is opposite to that of thyroxine. As a new chemical messenger ， T1AM can exert different pharmacological effects through a variety of receptors and signal pathways. This review summarizes the research progress of various pharmacological effects and mechanisms of exogenous T 1AM，in order to provide new therapeutic drugs of cardiovascular ，metabolic diseases and nervous system diseases.
