Predictive analysis of quality markers of Forsythia suspensa based on fingerprint and network pharmacology
- VernacularTitle:基于指纹图谱和网络药理学的连翘质量标志物预测分析
- Author:
Fengtang JING
1
;
Shuai FENG
1
,
2
;
Jing WANG
3
;
Xuzhen LYU
1
;
Tianyi ZHANG
1
;
Tianxi ZHANG
1
;
Feng LI
1
Author Information
1. School of Pharmacy，Shandong University of Traditional Chinese Medicine，Jinan 250355，China
2. Collaborative Innovation Center for Quality Control and Construction of Whole Industrial Chain for Traditional Chinese Medicine in Universities of Shandong Province，Jinan 250355，China
3. Dongying District Market Supervision and Administratio n Bureau in Dongying City，Shandong Dongy ing 257000，China
- Publication Type:Journal Article
- Keywords:
Forsythia suspensa;
quality marker;
fingerprint;
network pharmacology
- From:
China Pharmacy
2022;33(3):293-298
- CountryChina
- Language:Chinese
-
Abstract:
OBJ ECTIVE To predict the quality marker （Q-Marker）of Forsythia suspensa . METHODS The fingerprints of 10 batches of F. suspensa were established by high performance liquid chromatography. The common peaks were confirmed. The candidate components of Q-Marker in F. suspensa were screened. The volatile oil of F. suspensa were analyzed by gas chromatography-mass spectrometry （GC-MS），and the candidate components of Q-Marker in volatile oil were screened. The network pharmacology analysis was performed for the candidate components of Q-Marker. The network diagram of the “candidate components of F. suspensa Q-Marker-target-pathway”was constructed to predict the Q-marker of F. suspensa . RESULTS & CONCLUSIONS Twenty-one common peaks were obtained for 10 batches of F. suspensa ，and four components were identified as phillyrin，forsythoside A ，pinoresinol-4-O-β-D-glucoside and rutin. Seven candidate components were obtained by GC-MS analysis，such as β-pinene，α-pinene，terpinen-4-ol，limonene，γ-terpinene，α-phellandrene，β-myrcene. By network pharmacology analysis， 16 key targets and 17 pathways were obtained. It was preliminarily predicted that phillyrin ， forsythoside A ， pinoresinol-4-O-β-D-glucoside，rutin，terpinen-4-ol，α-phellandrene，α-pinene and β-pinene were Q-marker of F. suspensa .
