Impact of Toxoplasma gondii human infections on blood lipid levels
10.16250/j.32.1374.2021224
- VernacularTitle:人体刚地弓形虫感染对血脂水平的影响
- Author:
Li-feng WU
1
;
Xu-fang YE
1
Author Information
1. Department of Laboratory Medicine, The First People’s Hospital of Linping District, Hangzohu City, Hangzhou, Zhejiang 311100, China
- Publication Type:Journal Article
- Keywords:
Toxoplasma gondii;
Blood lipid;
Total cholesterol;
High-density lipoprotein;
Low-density lipoprotein;
Triglyceride
- From:
Chinese Journal of Schistosomiasis Control
2021;33(6):639-642
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the impact of Toxoplasma gondii human infections on blood lipid levels. Methods A total of 1 000 healthy volunteers that were randomly sampled from a tertiary hospital during the period from December 2017 through December 2019 were enrolled, and assigned into the infection group and the control group according to the detection of serum anti-T. gondii antibody using enzyme-linked immunosorbent assay (ELISA). The serum levels of total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglyceride (TG) were detected and compared between the two groups. Results The seroprevalence of anti-T. gondii antibody was 8.40% in the study subjects, and there were no significant differences between the infection and control groups in terms of gender (χ2 = 1.29, P > 0.05) or age (χ2 = 1.41, P > 0.05). The mean serum LDL (t = 3.89, P < 0.05) and TC levels (t = 3.81, P < 0.05) were significantly higher in the infection group than in the control group, while no significant differences were seen between the two groups in terms of mean serum TG (t = 0.97, P > 0.05) or HDL levels (t = 0.75, P > 0.05). In addition, the proportions of abnormal LDL (χ2 = 9.69, P < 0.01) and TC levels (χ2 = 10.39, P < 0.01) were significantly greater in the infection group than in the control group, while no significant differences were found in the proportion of abnormal TG (χ2 = 0.02, P > 0.05) or HDL level (χ2 = 0.11, P > 0.05) between the two groups. Conclusion T. gondii human infections affect blood lipid levels, and the individuals sero-positive for anti-T. gondii antibody have higher mean serum LDL and TC, as well as higher proportions of abnormal TC and LDL than sero-negative individuals.
