Progress of cell phenotypes and molecular subtypes as well as p53 gene abnormalities in the prognosis of diffuse large B-cell lymphoma
10.3760/cma.j.cn115355-20201124-00657
- VernacularTitle:细胞分型、分子亚型及p53基因异常在弥漫大B细胞淋巴瘤预后中的研究进展
- Author:
Jia GU
1
;
Jianxia HE
Author Information
1. 山西医科大学研究生院，太原 030001
- Keywords:
Lymphoma, large B-cell, diffuse;
Gene, p53;
Genotype;
Molecular biology;
Prognosis
- From:
Cancer Research and Clinic
2021;33(10):797-800
- CountryChina
- Language:Chinese
-
Abstract:
Diffuse large B-cell lymphoma (DLBCL) is a group of heterogeneous diseases, and further classification is of great value for prognostic stratification. In recent years, some subtypes with poor prognosis have been recognized, such as "double-hit" lymphoma or "double-expressing" lymphoma. In addition, the new molecular classification provides a new perspective for the accurate diagnosis and prognosis stratification of DLBCL. The mutation and deletion of p53 gene are high risk factors in the traditional sense of DLBCL, while with the application of the next generation sequencing and other technologies, the influence of more accurate gene mutation or deletion on prognosis and its prognostic value in new cell molecular subtypes still need to be further confirmed. This paper reviews the progress of cell phenotypes and molecular subtypes as well as p53 gene abnormalities in the prognosis of DLBCL.
