Progress of circulating tumor cells in primary bone tumor
10.3760/cma.j.cn115355-20210407-00160
- VernacularTitle:循环肿瘤细胞在原发性骨肿瘤中的研究进展
- Author:
Jifeng MIAO
1
;
Nenggan HUANG
;
Yun LIU
;
Chong LI
;
Xiaoting LUO
;
Shijie LIAO
;
Juliang HE
;
Zhaojie QIN
;
Tianyu XIE
;
Qingjun WEI
Author Information
1. 广西医科大学第一附属医院创伤骨科，南宁 530021
- Keywords:
Neoplastic cells, circulating;
Bone neoplasms;
Treatment outcome
- From:
Cancer Research and Clinic
2021;33(10):789-793
- CountryChina
- Language:Chinese
-
Abstract:
Some primary bone tumors are prone to hematogenous metastasis and after that, the therapeutic effect is not that good and prognosis is poor. Circulating tumor cells (CTC) shed from the tumor cells of primary or metastatic focus and then enter into blood circulation. CTC may appear in the early stage of the tumor, which can implant in distant organs to form metastatic sites and self-implant in the primary sites leading to the tumor recurrence; CTC are closely related with the prognosis of patients with tumors. In most primary bone tumors, CTC are heterogeneous compared with primary tumor cells. Studying CTC from various aspects can provide a basis for the early diagnosis and treatment of primary bone tumors. This review summarizes the current researches of CTC in common primary bone tumors, and expects the future of research direction and application practice in clinic.
