Progress of glioma-associated microglia and macrophage
10.3760/cma.j.cn115355-20200825-00481
- VernacularTitle:胶质瘤相关小胶质细胞和巨噬细胞的研究进展
- Author:
Jiangtao LIU
1
;
Shiyuan ZHANG
;
Kaixuan WANG
;
Changchen HU
Author Information
1. 山西医科大学附属人民医院神经外科，太原 030012
- Keywords:
Glioma;
Microglia;
Macrophage;
Molecular targeted therapy
- From:
Cancer Research and Clinic
2021;33(9):713-716
- CountryChina
- Language:Chinese
-
Abstract:
Glioma is a common tumor in the central nervous system. Because the natural immunosuppression of tumor microenvironment is conducive to tumor growth, transformation and migration, the traditional treatment has little effect and is difficult to make a breakthrough. Glioma-associated microglia and macrophage (GAM), an important part of brain tumor microenvironment, plays a more and more key role in tumor progression and regulation of anti-tumor immune response. This article reviews the latest progress of the source, recruitment, polarization and the role in development of gliomas as well as potential therapeutic targets of gliomas.
