Progress of non-coding RNA in angiogenesis of osteosarcoma
10.3760/cma.j.cn115355-20201130-00671
- VernacularTitle:非编码RNA在骨肉瘤血管新生中的研究进展
- Author:
Kai LUO
1
;
Yun LIU
;
Boxiang LI
;
Tianyu XIE
;
Wenyu FENG
;
Jianhong LIU
;
Xiaofei DING
;
Wei SU
;
Shijie LIAO
Author Information
1. 广西医科大学第一附属医院骨科，南宁 530021
- Keywords:
Osteosarcoma;
Angiogenesis;
microRNA;
Long non-coding RNA;
CircularRNA
- From:
Cancer Research and Clinic
2021;33(9):709-713
- CountryChina
- Language:Chinese
-
Abstract:
Osteosarcoma needs to continuously induce angiogenesis to satisfy its own nutritional supply in the process of development. Therefore, the inhibition of osteosarcoma cell-induced angiogenesis as a target has become a research hot in recent years. Currently, vascular inhibitors targeting mRNA-encoded protein have been applied in clinic, but the efficacy is poor. Non-coding RNA (ncRNA) is a type of RNA molecules that do not participate in protein coding. ncRNA can regulate the angiogenesis of osteosarcoma by regulating the secretion of vascular factors such as vascular endothelial growth factor, angiogenin-2 and hypoxia-inducible factor 1 or the interaction between ncRNAs. This article reviews the role of ncRNA in the angiogenesis of osteosarcoma to provide references for clinical targeted therapy strategies for osteosarcoma.
