Progress of erythropoietin-producing hepatocellular A2 receptor in glioma
10.3760/cma.j.cn115355-20201208-00694
- VernacularTitle:促红细胞生成素产生肝细胞受体2在脑胶质瘤中的研究进展
- Author:
Xiaoxue LIU
1
;
Jianrui LI
;
Zhongqiang LUO
;
Guangming LU
;
Zhiqiang ZHANG
Author Information
1. 南京大学医学院附属金陵医院（东部战区总医院）放射诊断科，南京 210002
- Keywords:
Glioma;
Receptor, EphA2;
Molecular targeted therapy
- From:
Cancer Research and Clinic
2021;33(9):702-705
- CountryChina
- Language:Chinese
-
Abstract:
Erythropoietin-producing hepatocellular A2 receptor (EphA2) is the most common subtype in the largest subfamily of the receptor tyrosine kinase superfamily, and is considered as a key factor in the regulation of malignant tumor progression. EphA2 is highly expressed in glioma, which plays an important role in the development and progression of glioma. This article reviews the structure, function, expression of EphA2 in glioma, and its role in glioma cell migration, maintenance of glioma stem cells, angiogenesis and targeted therapy.
