Progress of long non-coding RNA and circular RNA in cholangiocarcinoma
10.3760/cma.j.cn115355-20210109-00015
- VernacularTitle:长链非编码RNA及环状RNA在胆管癌中的研究进展
- Author:
Wujiang SHI
1
;
Jiangang WANG
;
Dongsheng WANG
;
Haoming XIA
;
Yi XU
;
Xiangyu ZHONG
Author Information
1. 哈尔滨医科大学附属第二医院胆胰外科，哈尔滨 150001
- Keywords:
Bile duct neoplasms;
Long non-coding RNA;
Circular RNA
- From:
Cancer Research and Clinic
2021;33(8):561-564
- CountryChina
- Language:Chinese
-
Abstract:
The insidious onset of cholangiocarcinoma and the lack of early diagnosis markers have made most patients diagnosed with cholangiocarcinoma in the advanced stage of the disease. At present, surgical treatment is the first choice for patients with cholangiocarcinoma, but surgery also faces problems such as high risks and many difficulties. Recent studies have found that long non-coding RNA (lncRNA) and circular RNA (circRNA) have the functions of regulating the cell proliferation, metastasis, invasion, epithelial-mesenchymal transition and drug resistance of cholangiocarcinoma. This article aims to review the potential regulatory role of lncRNA and circRNA in the occurrence and development of cholangiocarcinoma, in order to provide clinical references for the early diagnosis, targeted therapy and patient's prognosis evaluation of cholangiocarcinoma.
