Advances in molecular mechanism of berberine in treatment of glioma
10.3760/cma.j.cn115355-20210205-00075
- VernacularTitle:小檗碱治疗胶质瘤分子机制的研究进展
- Author:
Jiaqi HAO
1
;
Xingyue HE
;
Xin YANG
;
Yu ZHANG
;
Hao BAI
;
Hubin DUAN
Author Information
1. 山西医科大学第一临床医学院 030001
- Keywords:
Glioma;
Berberine;
Brain neoplasms;
MAP kinase signaling system;
Molecular biology
- From:
Cancer Research and Clinic
2021;33(7):557-560
- CountryChina
- Language:Chinese
-
Abstract:
Glioma is one of the most common primary intracranial tumors, accounting for 80% of malignant brain tumors. The conventional treatment of glioma is surgical resection followed by temozolomide chemotherapy, but the drug resistance will gradually appear that results in a poor prognosis of the patient. Berberine is an alkaloid extracted from Coptis Rhizoma, which has a wide range of pharmacological activities. It exerts its pharmacological effects on glioma such as inhibiting tumor growth through controlling different molecular and cellular pathways. In this article, the application of berberine in the treatment of glioma and the research progress of specific molecular mechanism are reviewed.
