Effect of CYP3A4*1G gene polymorphism on postoperative analgesia with fentanyl-related drugs: a Meta-analysis
10.3760/cma.j.cn115355-20200610-00312
- VernacularTitle:CYP3A4*1G基因多态性对芬太尼类药物术后镇痛效果影响的Meta分析
- Author:
Rong ZHOU
1
;
Rong KANG
;
Yimeng GUO
Author Information
1. 山西医科大学护理学院，太原 030001
- Keywords:
Polymorphism, single nucleotide;
Analgesia;
Pain, postoperative;
Fentanyl
- From:
Cancer Research and Clinic
2021;33(7):533-537
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically review the relationship between CYP3A4*1G gene polymorphism and the analgesic effect of fentanyl-related drugs.Methods:The related literature about the effect of gene polymorphism on analgesic effect of fentanyl-related drugs published at home and abroad was searched in PubMed, Embase, Cochrane Library, CNKI, Wanfang and China Biomedical Literature databases from database establishment to August 2019. According to the inclusion and exclusion criteria, two researchers screened the literature independently, extracted the data and evaluated the methodological quality. Data analysis was performed by Review Manager 5.1 software.Results:Six literature was enrolled with 1 050 cases, including 543 cases of wild-type homozygote (CC), 437 cases of heterozygote (CG) and 70 cases of mutant homozygote (GG). The results showed that there was no significant difference in pain score between the three groups in a pairwise comparison at 24 hours after operation (all P > 0.05), but the consumption of fentanyl-related drugs in GG group was lower than that in CC group and CG group, and the differences were statistically significant [GG group vs. CC group: standardized mean difference (SMD) = -0.78, 95% CI -1.03- -0.52, P<0.01; GG group vs. CG group: SMD = -0.61, 95% CI -0.87- -0.35, P<0.01]. Conclusions:CYP3A4*1G gene polymorphism can affect the postoperative analgesia effect of fentanyl-related drugs. With the same analgesic effect, the consumption of fentanyl-related drugs in GG patients is reduced.
