Progress of miRNA-27a in gastric cancer
10.3760/cma.j.cn115355-20200326-00151
- VernacularTitle:miRNA-27a在胃癌中的研究进展
- Author:
Jianyang YANG
1
;
De HE
Author Information
1. 南方医科大学第二临床医学院，广州 510280
- Keywords:
Gastric neoplasms;
miRNA-27;
Targeted gene;
Drug resistance, neoplasm;
Epithelial-mesenchymal transition;
Polymorphism, single nucleotide
- From:
Cancer Research and Clinic
2021;33(6):469-472
- CountryChina
- Language:Chinese
-
Abstract:
miRNA-27a (miR-27a) is a member of miR-23a-27a-24 gene cluster and is abnormally expressed in gastric cancer. miR-27a plays an important role in gastric cancer cell epithelial-mesenchymal transition, proliferation, microenvironment and resistance to chemotherapy drugs by regulating SFRP1, PHLPP2, BTG2, SOCS6, FOXO1 and other tumor suppressor genes. At the same time, single nucleotide polymorphisms of miR-27a and gastric cancer have also become hotspots in recent years. A more comprehensive exploration of the relationship between miR-27a and gastric cancer is expected to provide new methods and ideas in the treatment of gastric cancer. This article reviews the research progress of miR-27a in gastric cancer.
