Role of the stability of deoxyribonucleoside triphosphate pool in the development and progression of tumors

VernacularTitle:脱氧核糖核苷三磷酸池稳定性在肿瘤发生、发展中的作用
Author: Wei YU ¹ ; Jiajie ZHANG ; Li ZHANG ; Yunqing QIU
Author Information

1. 浙江大学医学院附属第一医院　传染病诊治国家重点实验室　国家感染性疾病临床研究中心　感染性疾病诊治协同创新中心　浙江省药物临床研究与技术重点实验室，杭州　310003
Keywords: Cell cycle; DNA damage; Genome stability; Nucleoside analogues
From: Cancer Research and Clinic 2021;33(6):460-464
CountryChina
Language:Chinese
Abstract: The stability of deoxyribonucleoside triphosphate (dNTP) pool is essential for the normal synthesis of nuclear and mitochondrial DNA. The lack or excess of any dNTP may cause DNA damage and genomic instability, and increase mutation rate. Present studies have confirmed that the instability of dNTP pool is closely related to a variety of tumorigenesis. In addition, dNTP pool is involved in the development of tumor via multiple pathways, while the mechanisms of tumors caused by the instability of dNTP are complicated. This paper discusses the relationship between the stability of dNTP pool and DNA damage repair to provide a theoretical basis for early diagnosis and targeted treatment of tumors.