Application of single cell sequencing technology in the cell analysis of cerebrospinal fluid
10.3760/cma.j.cn114452-20210121-00052
- VernacularTitle:单细胞测序技术在脑脊髓液细胞分析中的应用
- Author:
Haoyu RUAN
1
;
Chunrong GU
;
Ming GUAN
Author Information
1. 南京医科大学第一附属医院检验学部（江苏省人民医院），南京210000
- Keywords:
Cerebrospinal fluid;
Single-cell sequencing;
Central nervous system diseases
- From:
Chinese Journal of Laboratory Medicine
2021;44(10):960-963
- CountryChina
- Language:Chinese
-
Abstract:
The analysis of cerebrospinal fluid (CSF) facilitates the diagnosis and therapy of central nervous system (CNS) diseases. Compared to traditional methods, single-cell sequencing is conducive to analyze the cells composition and heterogeneity and discover scarce cells in CSF. Recent studies of single-cell sequencing in CSF has mainly focused on the neuroinfectious diseases, neurodegenerative and neuroinflammatory diseases, and leptomeningeal metastases (LM), reflecting the superiority and clinical value of single-cell sequencing in CNS diseases and providing new directions for the diagnosis and treatment of CNS diseases.
