Establishing reference intervals of serum anti-Müllerian hormone in women of childbearing age (20-34 years old) in Henan area
10.3760/cma.j.cn114452-20210129-00078
- VernacularTitle:河南地区20~34岁育龄女性血清抗苗勒管激素参考区间的建立
- Author:
Yongjun YANG
1
;
Mengya WANG
;
Lixing CAO
;
Dan CHEN
;
Ming LI
;
Xiaolan GUO
;
Yafei SUN
Author Information
1. 河南省生殖健康科学技术研究院 国家卫生健康委出生缺陷预防重点实验室 河南省人口缺陷干预技术研究重点实验室，郑州 450002
- Keywords:
Anti-Mullerian hormone;
Reference intervals;
Childbearing age women
- From:
Chinese Journal of Laboratory Medicine
2021;44(10):921-925
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the serum anti-Müllerian hormone (AMH) levels in women of childbearing age in different age groups in Henan, and establish the medical reference intervals based on measurement results from this population.Methods:From January to June 2017, 620 healthy women of childbearing age (20-34 years old), who underwent pre-pregnancy eugenics and pre-marital checkups in 13 project sites in Henan, were included in this study. Participants were divided into 3 age groups: 20-24 years group ( n=210), 25-29 years group ( n=207), and 30-34 years group ( n=203). Spearman correlation coefficient was used to evaluate the correlation between serum AMH level and age; Kruskal-Wallis H test was used to compare the serum AMH levels of different age groups; Wilcoxon test was used for comparison between pairs; the percentile method ( P2.5, P97.5) was used to establish medical reference interval of serum AMH in women of childbearing age for the whole population and different age groups, respectively. Results:The correlation coefficient between serum AMH and age in women of childbearing age (20-34 years old) is -0.17 ( P<0.001). There was a statistically significant difference in the overall frequency distribution of serum AMH levels among the three different age groups ( H=21.978, P<0.05). Among them, there is a statistically significant difference between the 20-24 years group and the 30-34 years group ( Z=4.292, P<0.05). There is a statistically significant difference between the 25-29 years group and the 30-34 years group ( Z=3.803, P<0.05). The reference range of serum AMH is 0.281-9.693 μg/L in this cohort; the reference range of serum AMH is 0.524-10.760, 0.229-9.200, 0.115-8.200 μg/L for women of childbearing age at 20-24, 25-29 and 30-34 years, respectively. Conclusion:The serum AMH level of women of childbearing age (20-34 years old) decreases with age. It is of great significance to establish the serum AMH reference interval for women of childbearing age in different age groups in Henan.
