Role of immunoglobulin glycosylation in autoimmune diseases
10.3760/cma.j.cn114452-20201224-00923
- VernacularTitle:免疫球蛋白糖基化在自身免疫性疾病中的作用
- Author:
Xiaoli ZENG
1
;
Guoyuan ZHANG
;
Chaojun HU
Author Information
1. 川北医学院附属医院输血科，南充637000
- Keywords:
Immunoglobulins;
Glycosylation;
Autoimmune diseases;
Immunoglobulin G
- From:
Chinese Journal of Laboratory Medicine
2021;44(9):868-872
- CountryChina
- Language:Chinese
-
Abstract:
Glycosylation is one of the most important post-translational modification in protein biosynthesis. Immunoglobulin glycosylation can exert anti-inflammatory or pro-inflammatory activity by regulating antibody stability and affecting its interaction with different FcγRs. In recent years, a large number of studies have confirmed that abnormal glycosylation of immunoglobulin plays a key role in the pathogenesis of autoimmune diseases. Its products, such as sugar chain structure or/and glycosylated proteins, can be detected by lectin microarray and other technologies, are expected to become new serum markers of autoimmune diseases. It has a broad application prospect in disease diagnosis, condition monitoring, prognosis evaluation and treatment.
