Application of liquid chromatography-tandem mass spectrometry in the clinical diagnosis and treatment of adrenal incidentaloma
10.3760/cma.j.cn114452-20210403-00213
- VernacularTitle:液相色谱-串联质谱在肾上腺偶发瘤临床诊疗中的应用
- Author:
Ziyun CHENG
1
;
Wei GUO
Author Information
1. 复旦大学附属中山医院检验科，上海200032
- Keywords:
Liquid chromatography tandem mass spectrometry;
Adrenal incidentaloma
- From:
Chinese Journal of Laboratory Medicine
2021;44(8):669-673
- CountryChina
- Language:Chinese
-
Abstract:
With the development of diagnostic techniques, the diagnosis rate of adrenal incidental tumors is increasing. Disease related hormones can be detected to evaluate the endocrine function of tumors for diagnosis and treatment, especially by liquid chromatography-tandem mass spectrometry (LC-MS/MS). LC-MS/MS has the advantages of high sensitivity, specificity and multi-component, and has become the gold standard method for the detection of small molecule hormones.Mass spectrometry has advantages in the detection of glucocorticoids, halo corticoids, sex hormones and catecholamine metabolites.LC-MS/MS still has some limitations in clinical practice, which are manifested as low degree of automation and lack of standardization.After the improvement of the clinical application of LC-MS/MS and the establishment of reference scope, the clinical judgment on the endocrine function of AI will be more standardized.
