Research progress of growth differentiation factor-15 in disease of cardiovascular system
10.3760/cma.j.cn114452-20200914-00726
- VernacularTitle:生长分化因子-15在心血管疾病中的研究进展
- Author:
Runan ZHANG
1
;
Hui YUAN
Author Information
1. 首都医科大学附属北京安贞医院检验科，北京100029
- Keywords:
Growth differentiation factors;
Cardiovascular diseases
- From:
Chinese Journal of Laboratory Medicine
2021;44(7):644-647
- CountryChina
- Language:Chinese
-
Abstract:
Growth differentiation factor-15 (GDF-15) is a distant branch of the transforming growth factor-β (TGF-β) superfamily. Recent studies indicate that GDF-15 plays important physiological roles and has clinical implication in the initiation and development of various cardiovascular diseases. GDF-15 can both be used as a biomarker for the evaluation of cardiovascular disease occurrence and progression and a predictor for the risk stratification and long-term prognosis of cardiovascular diseases. The purpose of this review is to illustrate the latest research progress of GDF-15 in atherosclerosis and acute coronary syndrome obtained through the clinical research and basic experiments in cardiovascular diseases, to provide evidence for the selection of GDF-15 as useful biomarkers in the diagnosis and treatment of cardiovascular diseases.
