Meaning of targeting non-high-density lipoprotein cholesterol in lipid-lowering therapy
10.3760/cma.j.cn114452-20210407-00219
- VernacularTitle:非高密度脂蛋白胆固醇作为降脂治疗目标的意义
- Author:
Yang YANG
1
;
Daoquan PENG
Author Information
1. 中南大学湘雅二医院心内科，长沙 410011
- Keywords:
Coronary artery disease;
Low-density lipoprotein cholesterol;
Non-high-density lipoprotein cholesterol
- From:
Chinese Journal of Laboratory Medicine
2021;44(7):569-573
- CountryChina
- Language:Chinese
-
Abstract:
Low-density lipoprotein cholesterol (LDL-C) has been recommended as the primary treatment target on lipid management in coronary heart disease (CHD) patients for several decades. However, even by aggressive LDL-C lowering treatment, patients still present a significant residual risk of major adverse cardiovascular events. Non-high-density lipoprotein cholesterol (non-HDL-C) contained all the atherogenic lipoproteins. Non-HDL-C is superior to LDL-C for the prediction of cardiovascular events and has many other compelling advantages over LDL-C and other traditional lipid parameters. This review mainly discusses the definition and test advantages of non-HDL-C, the predictive value of non-HDL-C, recommended value of non-HDL-C goals, and related guideline recommendations of non-HDL-C.
