The progress on the role of miR-126 in the pathogenesis, diagnosis and treatment of diabetic retinopathy
10.3760/cma.j.cn511434-20201103-00531
- VernacularTitle:miR-126在糖尿病视网膜病变发病机制及诊疗应用中的作用研究进展
- Author:
Rui WANG
1
;
Xiangxia LUO
;
Tingting HU
;
Yujie ZHANG
Author Information
1. 甘肃中医药大学中医临床学院，兰州 750000
- Keywords:
Diabetic retinopathy;
Microvessels;
Review;
miR-126
- From:
Chinese Journal of Ocular Fundus Diseases
2021;37(11):906-910
- CountryChina
- Language:Chinese
-
Abstract:
Microvascular dysfunction is a key pathological mechanism of diabetic retinopathy (DR). In recent years, it has been found that the phenomenon of "metabolic memory" is prevalent in diabetic patients, and diabetic microangiopaplasia cannot be avoided even if patients' blood glucose is well controlled. Therefore, it is necessary to explore DR from a genetic perspective. miR-126 is the unique microRNA specifically expressed in vascular endothelial cells, which is closely related to the formation of neovascularization and can affect the stability of DR microvessels as well as the germination and migration of endothelial cells, and its gene level is significantly negatively correlated with the expression of vascular endothelial cell growth factor. The potential value of intracellular and circulating miR-126 in the regulation of DR microvascular homeostasis, early diagnosis and treatment, and monitoring of disease course has attracted great attention. However, studies in this area are mostly hypothesis-driven and still have some limitations. It is believed that with the rapid development of genomics, the miRNA spectrum and its molecular mechanism in eye development and eye diseases will gradually become clear, which may lead to a breakthrough in the intervention of individual refractory retinal diseases and establish a new miRNA diagnosis and treatment method in the future.
