Progress and challenges in diagnosis and treatment of Leber's hereditary optic neuropathy
10.3760/cma.j.cn511434-20210727-00399
- VernacularTitle:Leber遗传性视神经病变诊治进展与挑战
- Author:
Libin JIANG
1
;
Sitong GUO
Author Information
1. 首都医科大学附属北京同仁医院 北京同仁眼科中心 100730
- Keywords:
Optic atrophy, hereditary, Leber;
Editorial
- From:
Chinese Journal of Ocular Fundus Diseases
2021;37(10):749-752
- CountryChina
- Language:Chinese
-
Abstract:
Leber's hereditary optic neuropathy (LHON) is a rare hereditary optic nerve disease. At present, the understanding of its etiology and pathogenesis is relatively clear. With the emergence of new drugs such as idebenone and the possibility of gene therapy for LHON, it has brought hope for patients to recover. However, because genetic testing technology has not been widely developed in China, clinical misdiagnosis of LHON as optic neuritis still occurs from time to time. How to make timely identification and correct diagnosis of LHON still poses certain challenges for Chinese ophthalmologists. In addition, in terms of treatment, the choice of treatment methods and treatment costs in the pre-onset (gene mutation carriers) and different periods after the onset of LHON are also huge challenges for patients and their families.
