Prevalence of Serum IgG Antibodies to Cystic Echinococcus Antigen among Patients in an Uzbekistan Emergency Hospital.
10.3347/kjp.2015.53.6.699
- Author:
Se Jin PARK
1
;
Sung Sik HAN
;
Khikmat ANVAROV
;
Abdukhakim KHAJIBAEV
;
Min Ho CHOI
;
Sung Tae HONG
Author Information
1. School of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea.
- Publication Type:Original Article
- Keywords:
Echinococcus granulosus;
cystic echinococcosis;
serum antibody;
ELISA;
positive rate;
asymptomatic patient;
Uzbekistan
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Animals;
Antibodies, Helminth/*blood;
Child;
Child, Preschool;
Echinococcosis/*blood/epidemiology/parasitology;
Echinococcus/*immunology/isolation & purification;
Emergency Service, Hospital;
Enzyme-Linked Immunosorbent Assay;
Female;
Humans;
Immunoglobulin G/*blood;
Male;
Middle Aged;
Prevalence;
Uzbekistan/epidemiology;
Young Adult
- From:The Korean Journal of Parasitology
2015;53(6):699-703
- CountryRepublic of Korea
- Language:English
-
Abstract:
Cystic echinococcosis (CE) is one of the most widespread zoonotic helminthiases, which can last an asymptomatic infection for several years. The purpose of this study was to demonstrate serum antibody prevalence of CE among asymptomatic people in Uzbekistan using ELISA. A total of 2,547 serum samples were collected, 66 from confirmed CE patients and 2,481 of patients with other diseases than CE at a hospital in Tashkent, Uzbekistan. The serum samples were screened for CE specific IgG antibodies by ELISA using cystic fluid antigen obtained from sheep. The serum antibody positive rate was 89.4% (59/66) in CE and 3.6% (89/2,481) in other disease patients. The present ELISA recognized 89.4% sensitivity and 96.4% specificity. The ELISA absorbance of positive samples was distributed 0.271-0.971 for CE and 0.273-0.887 for other disease patients. The other disease patients with high absorbance over 0.3 were 50 (2.0%) who were presumed to be active CE patients. The patients in their 40s showed the highest positive rate of 5.2% (P=0.181), and women were 4.4% while men were 3.1% positive (P=0.136). The data confirmed that there are many asymptomatic patients of CE in Tashkent. It is indicated that CE is an endemic disease of public health importance in Uzbekistan.
