Advances in the role and mechanism of autologous mitochondrial transplantation in myocardial protection from ischemia and reperfusion
10.3760/cma.j.cn112434-20200807-00367
- VernacularTitle:自体线粒体移植在缺血再灌注心肌保护中的作用及机制研究进展
- Author:
Cong LI
1
;
Yanjun PAN
;
Zhongqun ZHU
Author Information
1. 上海交通大学医学院附属上海儿童医学中心心胸外科 200127
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2021;37(10):631-634
- CountryChina
- Language:Chinese
-
Abstract:
In cardiac surgery such as myocardial infarction, congenital heart disease, and heart transplantation, myocardial ischemia-reperfusion (I/R) damages mitochondria, which in turn causes myocardium energy metabolism disturbance, homeostatic destruction, reactive oxygen species production and DNA damage, and activates myocardium apoptosis and necrosis signals, which eventually lead to myocardial dysfunction or heart failure. Different from the previous I/R treatment targets focusing on a certain pathway or a certain medium, autologous mitochondrial transplantation (AMT) is an emerging method, which transplant viable and respiration-competent mitochondria from healthy organs or tissues to the injured sites which suffer from I/R injury, to replace or repair damaged mitochondria. In recent years, AMT has achieved remarkable results in the prevention and treatment of myocardial I/R. This article reviews the role and mechanism of AMT in I/R myocardial protection.
