Research of the correlation between α1-antitrypsin and acute kidney injury after cardiopulmonary bypass
10.3760/cma.j.cn112434-20200324-00154
- VernacularTitle:α1-抗胰蛋白酶与体外循环心脏手术后急性肾损伤相关性研究
- Author:
Xuefeng LIN
1
;
Peng ZHU
;
Songlin DU
;
Pengyu ZHOU
;
Shaoyi ZHENG
Author Information
1. 南方医科大学南方医院心血管外科，广州 510515
- Keywords:
Alpha 1-antitrypsin;
Acute kidney injury;
Cardiopulmonary bypass;
Oxidative stress
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2021;37(6):363-366
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To figure out variety of the plasma level of Alpha-1-Antitrypsin(α1-AT) in patients who undergo AKI following cardiopulmonary bypass(CPB), and whether this biomarker serve as a competent predictor.Methods:We recruited 75 patients undergoing cardiac surgery with CPB from January 2018 to January 2019. Patients were categorized into two groups according to the development of AKI. The relationship between plasma concentration of α1-AT and renal injury in two groups was analyzed.Results:27 patients in the AKI group were aged (54.3±12.2)years old, including 15 males and 12 females, the time of cardiopulmonary bypass was(133.5±34.7)min. In the non-AKI group, 48 cases were aged(47.7±11.3)years old, including 26 males and 22 females, and the time of cardiopulmonary bypass was(133.5±34.7)min. α1-AT was significantly decreased in AKI group at 1 h after operation[(0.53±0.53)g/L vs. (1.46±0.91)g/L, P<0.05]compared with the non-AKI group. The sensitivity and specificity of α1-antitrypsin level at 1h after operation was the highest when α1-AT was 0.675 g/L. CPB time ( OR=5.890, 95% CI: 1.078-32.173) and age ( OR=4.427, 95% CI: 1.113-17.614) were independent risk factors for AKI after surgery, and α1-AT at 1h after CPB ( OR=0.084, 95% CI: 0.021-0.333) were protective factors after operation. Conclusion:Increased concentration of α1-AT after cardiopulmonary bypass at early time is a protective factor for AKI and the concentration of α1-AT in plasma could be used as an early biomarker of AKI after CPB.
