Role of exosomes in regeneration of peripheral nerve after injury and the progress in application
10.3760/cma.j.cn441206-20210623-00162
- VernacularTitle:外泌体在周围神经损伤修复中的作用及应用进展
- Author:
Zhuoxuan LI
1
;
Haodong LIN
Author Information
1. 上海交通大学附属第一人民医院创伤临床医学中心，上海 201600
- Keywords:
Exosomes;
Peripheral nerve injuriy;
Macrophages;
Schwann cells;
Mesenchymal stem cells
- From:
Chinese Journal of Microsurgery
2021;44(5):591-594
- CountryChina
- Language:Chinese
-
Abstract:
Peripheral nerve injury is common in clinical practice. Today, outcomes of peripheral nerve repair are still not satisfactory. Recently, a large number of studies have shown that exosomes and their bioactive substances can repair peripheral nerve injury by mediating axonal regeneration, activating Schwann cells, regulating inflammation and other pathways to restore nerve function. This review aims to summarise and prospect the role and application of exosomes in peripheral nerve repair from the perspective of Schwann cells, mesenchymal stem cells and macrophages derived exosomes and their bioactive substances.
