Pathological Lesions and Inducible Nitric Oxide Synthase Expressions in the Liver of Mice Experimentally Infected with Clonorchis sinensis.
10.3347/kjp.2015.53.6.777
- Author:
Qing Li YANG
1
,
2
,
3
;
Ji Qing SHEN
;
Yan XUE
;
Xiao Bing CHENG
;
Zhi Hua JIANG
;
Yi Chao YANG
;
Ying Dan CHEN
;
Xiao Nong ZHOU
Author Information
1. National Institute of Parasitic Disease, Chinese Center for Disease Control and Prevention
2. Key Laboratory of Parasite and Vector Biology, Ministry of Health
3. WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai 200025, P. R. China. ipdzhouxn@sh163.net
- Publication Type:Brief Communication ; Research Support, Non-U.S. Gov't
- Keywords:
Clonorchis sinensis;
pathology;
inducible nitric oxide synthase;
liver;
immunohistochemistry
- MeSH:
Animals;
Clonorchiasis/*enzymology/genetics/parasitology/*pathology;
Clonorchis sinensis/*physiology;
Female;
Humans;
Liver/*enzymology/parasitology/pathology;
Mice;
Mice, Inbred BALB C;
Nitric Oxide Synthase Type II/*genetics/metabolism
- From:The Korean Journal of Parasitology
2015;53(6):777-783
- CountryRepublic of Korea
- Language:English
-
Abstract:
The nitric oxide (NO) formation and intrinsic nitrosation may be involved in the possible mechanisms of liver fluke-associated carcinogenesis. We still do not know much about the responses of inducible NO synthase (iNOS) induced by Clonorchis sinensis infection. This study was conducted to explore the pathological lesions and iNOS expressions in the liver of mice with different infection intensity levels of C. sinensis. Extensive periductal inflammatory cell infiltration, bile duct hyperplasia, and fibrosis were commonly observed during the infection. The different pathological responses in liver tissues strongly correlated with the infection intensity of C. sinensis. Massive acute spotty necrosis occurred in the liver parenchyma after a severe infection. The iNOS activity in liver tissues increased, and iNOS-expressing cells with morphological differences were observed after a moderate or severe infection. The iNOS-expressing cells in liver tissues had multiple origins.
