Endoscopic and histological characteristics of Helicobacter pylori-negative early gastric cancer
10.3760/cma.j.cn321463-20201031-00270
- VernacularTitle:幽门螺杆菌阴性早期胃癌的内镜及组织学特点分析
- Author:
Hui SU
1
;
Peng JIN
;
Lang YANG
;
Yuqi HE
;
Xiaojun ZHAO
;
Haihong WANG
;
Na LI
;
Jianqiu SHENG
Author Information
1. 解放军总医院第七医学中心消化内科，北京 100700
- Keywords:
Helicobacter pylori;
Gastroscopy;
Early gastric cancer;
Helicobacter pylori-negative gastric cancer
- From:
Chinese Journal of Digestive Endoscopy
2021;38(7):551-555
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the endoscopic and histological characteristics of Helicobacter pylori ( HP)-negative early gastric cancer (EGC) and high grade intraepithelial neoplasia (HGIN). Methods:Data of patients diagnosed as having EGC or HGIN confirmed by pathology at the Seventh Medical Center of Chinese People′s Liberation Army General Hospital from January 2013 to January 2020 were collected. Patients were included according to the diagnostic criteria of HP-negative gastric cancer, and their endoscopic features and histopathological characteristics were retrospectively analyzed. Results:Among 469 lesions of EGC/HGIN, HP-negative lesions accounted for 2.1% (10/469), which included 3 signet ring cell carcinomas, 3 fundic gland type carcinomas, 1 foveolar adenocarcinoma, 1 HGIN of the cardia, 1 familial adenomatous polyposis with gastric HGIN, and 1 Lynch syndrome with gastric HGIN. The 3 cases of signet ring cell carcinoma were all whitish flat/depressed lesions and commonly seen in the lower part of the stomach (2/3). Most of the 7 cases of differentiated EGC/HGIN were elevated type (5/7) and commonly seen in the upper and middle stomach (6/7). Conclusion:HP-negative EGCs are usually solitary lesions under gastroscopy. Undifferentiated type mostly appears whitish flat/depressed in the lower part of the stomach, while differentiated type appears elevated in the upper and middle part.
