Human coronavirus OC43 and its correlation with SARS-CoV-2

VernacularTitle:人冠状病毒OC43和SARS-CoV-2的相关性与启示
Author: Yarong ZENG ¹ ; Zhigang ZHANG ; Lijie REN ; Qinjian ZHAO
Author Information

1. 厦门大学公共卫生学院，分子疫苗学和分子诊断学国家重点实验室，国家传染病诊断试剂与疫苗工程技术研究中心　361102
Keywords: HCoV-OC43; SARS-CoV-2; Epidemiology; Genomics; Phyletic evolution; Clinical diagnosis
From: Chinese Journal of Microbiology and Immunology 2021;41(11):821-828
CountryChina
Language:Chinese
Abstract: Human coronavirus OC43 (HCoV-OC43) and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) belong to the β-coronavirus genus. Since the discovery in 1967, HCoV-OC43 has been continuously circulating in human population and has become one of the common seasonal respiratory viruses. SARS-CoV-2, which has a higher morbidity and fatality rate, appeared at the end of 2019, followed by the emergence of a variety of variants, and the transmission and infection capacity of SARS-CoV-2 has been enhanced. HCoV-OC43 may be similar to SARS-CoV-2 in terms of genomic structure and function, species evolution, epidemic characteristics and clinical manifestations. In this review, the epidemiology, genomics, phylogenetic evolution and other aspects of HCoV-OC43 and SARS-CoV-2 were analyzed. Such an analysis would be helpful to understand the association and differences between the two viruses, and provide reference for understanding the potential threats of HCoV-OC43.