Progress in the structure and function of rotavirus non-structural protein 4

VernacularTitle:轮状病毒非结构蛋白4结构与功能的研究进展
Author: Xiangyao QUE ¹ ; Shanfeng ZHANG ; Mingchen WANG ; Peng WANG
Author Information

1. 郑州大学基础医学院生物化学与分子生物学系　450000
Keywords: Rotavirus; Non-structural protein; NSP4
From: Chinese Journal of Microbiology and Immunology 2021;41(10):817-820
CountryChina
Language:Chinese
Abstract: Rotavirus (RV) is one of the main pathogens causing diarrhea in children under five years old, but the mechanism of RV-infected diarrhea is still unclear. The RV genome encodes six structural proteins (VP1-VP4, VP6 and VP7) and six non-structural proteins (NSP1-NSP6), among which NSP4 can interact with other non-structural proteins or structural proteins of RV to produce corresponding biological functions, and is a key factor in the formation of RV morphology, the process of infection and the pathogenesis of diarrhea. In this paper, the current domestic and foreign studies on the structure and function of NSP4 are reviewed.