Progress in interactions between rotavirus infection and innate immunity
10.3760/cma.j.cn112309-20210106-00006
- VernacularTitle:轮状病毒感染与宿主固有免疫研究进展
- Author:
Feibo SONG
1
;
Yuanjun ZENG
;
Tingdong LI
;
Shengxiang GE
Author Information
1. 厦门大学生命科学学院，国家传染病诊断试剂与疫苗工程技术研究中心 361101
- Keywords:
Rotavirus;
Innate immunity;
Interferon;
Immune escape
- From:
Chinese Journal of Microbiology and Immunology
2021;41(10):811-816
- CountryChina
- Language:Chinese
-
Abstract:
Rotavirus (RV) is one of the leading causes of acute gastroenteritis in infants and young animals worldwide. Rotavirus infection has obvious species specificity and mainly causes diarrhea in infants and young animals. The host innate responses suppress the infection and replication of rotavirus through activating multiple signaling pathways. Meanwhile, rotavirus also antagonizes the innate immune responses in various ways. This article reviewed the mechanisms of host innate immune responses to rotavirus infection and the antagonistic mechanism of rotavirus against host innate immunity with a view to providing reference for the development of therapeutic drugs and the prevention of rotavirus infection.
