Regulatory effects of plant polysaccharides on tumor-associated macrophages (TAMs): progress and perspectives
10.3760/cma.j.cn112309-20201228-00574
- VernacularTitle:植物多糖对肿瘤相关巨噬细胞调节作用的研究进展
- Author:
Jie LI
1
;
Yajun ZHANG
;
Linru ZHAO
;
Jingxing JIANG
;
Yuxia HE
;
Xuliang HAO
Author Information
1. 山西省中医药研究院中药方剂研究所，太原 030012
- Keywords:
Plant polysaccharides;
Tumor-associated macrophages;
Immunotherapy
- From:
Chinese Journal of Microbiology and Immunology
2021;41(9):736-740
- CountryChina
- Language:Chinese
-
Abstract:
With the appearance of the disadvantages of traditional tumor treatment, immunotherapy has entered people′s horizons as modern emerging treatment strategies, among which plant polysaccharides have received much more attention due to their antitumor activity and significant immunomodulatory effects. Tumor-associated macrophages (TAMs), as a component of tumor microenvironment, are important factors affecting tumors, and the regulation of TAMs by plant polysaccharides is one of the effective immunotherapy to treat tumor. In this review, we mainly described the regulation of TAMs by plant polysaccharides and the underlying mechanisms, and then gave an outlook on the research interests and the development of plant polysaccharides as immune adjuvants, aiming to provide reference for the study of plant polysaccharides in the immunotherapy for tumors.
