Dual role of exosomes in viral infection: immune activation and immune escape
10.3760/cma.j.cn112309-20201021-00484
- VernacularTitle:外泌体在病毒感染中的双重作用：免疫激活及免疫逃逸
- Author:
Yuantao ZHOU
1
;
Xiaoli HE
;
Yu ZHANG
;
Lyuyan TAO
;
Xiaoning LIU
;
Haifeng LIU
;
Li LI
Author Information
1. 昆明市儿童医院 云南省儿科研究所 650228
- Keywords:
Exosomes;
Viral infection;
Immune activation;
Immune escape
- From:
Chinese Journal of Microbiology and Immunology
2021;41(9):731-735
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are extracellular vesicles containing a variety of cell membrane molecules and related protein. They have been found to act as important intercellular messengers carrying functional RNAs, proteins and lipids that can induce phenotypic changes in recipient cells and promote cell activation or inhibition effect. In recent years, some studies have shown that exosomes can not only play an immune activation role to trigger antiviral immune response after viral infection, but also help to spread virus among cells, thus contributing to viral immune escape. Exosomes can either spread or limit an infection depending on the type of pathogen and the features of source cells, and can be studied as potential targets for development of antiviral drugs and vaccines. This review summarized the role of exosomes in viral infections with an emphasis on their potential contribution to pathogenesis.
