Molecular characteristics and mechanisms in related diseases of peptidylarginine deiminase from Porphyromonas gingivalis
10.3760/cma.j.cn112309-20201229-00575
- VernacularTitle:牙龈卟啉单胞菌肽酰基精氨酸脱亚氨酶的分子特征及在相关疾病中的作用机制
- Author:
Jiaxiang MO
1
;
Siyu SUN
;
Jiayin HUANG
;
Hongbing GUAN
;
Xuechun FANG
;
Yanling ZHENG
;
Saisai REN
Author Information
1. 广州医科大学附属口腔医院口腔基础医学教研室，广州市口腔再生医学基础与应用研究重点实验室 510182
- Keywords:
Porphyromonas gingivalis peptidylarginine deiminase;
Citrullination;
Periodontal disease;
Rheumatoid arthritis
- From:
Chinese Journal of Microbiology and Immunology
2021;41(8):650-655
- CountryChina
- Language:Chinese
-
Abstract:
Porphyromonas gingivalis peptidylarginine deiminase (PPAD), an isoenzyme of animal endogenous peptidylarginine deaminase, is secreted by the Por system and catalyzes the citrullination of arginine. Recent studies have found that PPAD can affect the formation of Porphyromonas gingivalis biofilm and reduce the body′s immune defense function, which is related to the occurrence and development of many diseases such as periodontal diseases and rheumatoid arthritis. In this paper, we reviewed the molecular characteristics of PPAD, including the genetic and functional characteristics, as well as the mechanisms related to the inflammatory and autoimmune diseases. We also pointed some issues that should be pay attention to in the further study.
