Research progress on the function of circular RNA in the interaction between virus and host
10.3760/cma.j.cn112309-20201113-00517
- VernacularTitle:环状RNA在病毒与宿主相互作用中功能的研究进展
- Author:
Daining ZHANG
1
;
Xiuhua YU
;
Shu ZHANG
;
Ming DUAN
Author Information
1. 吉林大学动物医学学院，人兽共患病研究所，人兽共患病研究教育部重点实验室，长春 130062
- Keywords:
circRNA;
Virus;
Infection
- From:
Chinese Journal of Microbiology and Immunology
2021;41(8):645-649
- CountryChina
- Language:Chinese
-
Abstract:
Circular RNAs (circRNAs), a novel type of non-coding RNAs (ncRNAs), are generated from pre-mRNA by covalently backsplicing of a downstream 5′ splice donor site onto an upstream 3′ splice acceptor site. Recent studies have shown that circRNAs have diverse biological functions, such as acting as a miRNA sponge to repress miRNA function, participating in splicing of target genes and translating genes into protein. These functions are involved in pathogenesis and progression of many diseases, including viral infection. In this review, we provided a brief introduction on the biological characteristics and functions of circRNAs, and summarized recent findings on the emerging roles of circRNA in viral infections, which might provide a new angle to study pathogenic characteristics and to understand the virus-host interaction mechanism.
