Development of mRNA vaccine and its research in influenza
10.3760/cma.j.cn112309-20200925-00451
- VernacularTitle:mRNA疫苗的开发及在流感中的研究
- Author:
Jian SONG
1
;
Xueliang WANG
Author Information
1. 上海市临床检验中心分子生物学室 200126
- Keywords:
mRNA vaccine;
Influenza;
Delivery system;
Immunogenicity
- From:
Chinese Journal of Microbiology and Immunology
2021;41(7):571-576
- CountryChina
- Language:Chinese
-
Abstract:
Influenza is an acute infectious disease of the respiratory tract and has posed a serious threat to human health. Vaccination is the most effective way to prevent influenza. The traditional inactivated or attenuated live vaccine based on chicken embryo has a long production cycle. Additionally, the surface antigens of vaccine strains and epidemic strains often do not match due to the continuous antigen drift or shift of influenza virus. As a result, the effectiveness of influenza vaccine is significantly reduced, so there is an urgent need to find a rapid and efficient influenza vaccine production strategy to overcome this limitation. In recent years, with the development of genetic engineering technology and various delivery systems, nucleic acid vaccine has been well developed, especially mRNA vaccine has attracted wide attention because of its simple production process and good safety. Therefore, mRNA-based vaccine immunization strategy provides a new direction for the prevention of influenza. This article reviews the molecular design, delivery system and research in influenza in the development of mRNA vaccine, in order to provide a reference basis for the research and development of influenza mRNA vaccine.
