Progress of phagosome maturation and function in neutrophil, macrophage and dendritic cell
10.3760/cma.j.cn112309-20200828-00416
- VernacularTitle:中性粒细胞、巨噬细胞和树突状细胞吞噬体成熟及其功能研究进展
- Author:
Tingting ZHANG
1
;
Yijie LI
;
Jinyao LI
Author Information
1. 新疆大学生命科学与技术学院，新疆生物资源基因工程重点实验室，乌鲁木齐 830046
- Keywords:
Phagosome maturation;
Functional differences;
Antigen presentation
- From:
Chinese Journal of Microbiology and Immunology
2021;41(7):565-570
- CountryChina
- Language:Chinese
-
Abstract:
Phagosomes undergo the fusion of early endosomes, late endosomes and lysosomes, and then degrade antigens and kill pathogenic microorganisms, which is called phagosome maturation. The functional differences of phagosomes after maturation in different immune cells lead to distinct characteristics on their processing of phagocytic antigens. It has been found that the antigen degradation ability of immune cells is opposite to their antigen presentation capacity through comparing the functional differences of phagosomes from neutrophils, macrophages and dendritic cells after antigens uptake. Among them, dendritic cells have the strongest antigen presentation capacity, followed by macrophages and neutrophils. The in-depth study of immune cell phagosome maturation and antigen presentation will provide new strategies for vaccine development and immunotherapy.
