Dehydroepiandrosterone and cortisol concentrations in the cerebrospinal fluid of dogs.
10.14405/kjvr.2017.57.1.47
- Author:
Paolo MONGILLO
1
;
Marco BERNARDINI
;
Elisa PRANA
;
Federica BALDUCCI
;
Gianfranco GABAI
;
Lieta MARINELLI
Author Information
1. Department of Comparative Biomedicine and Food Sciences, University of Padova, Legnaro 35020, Italy. paolo.mongillo@unipd.it
- Publication Type:Brief Communication
- Keywords:
cerebrospinal fluid;
dehydroepiandrosterone;
dogs;
hydrocortisone;
sex
- MeSH:
Animals;
Brain;
Cerebrospinal Fluid*;
Dehydroepiandrosterone*;
Diagnosis;
Dogs*;
Epilepsy;
Female;
Humans;
Hydrocortisone*;
Male;
Radioimmunoassay
- From:Korean Journal of Veterinary Research
2017;57(1):47-50
- CountryRepublic of Korea
- Language:English
-
Abstract:
Concentrations of cortisol, dehydroepiandrosterone and dehydroepiandrosterone-sulfate were measured by performing radioimmunoassay of the cerebrospinal fluid of 68 dogs diagnosed with idiopathic epilepsy or inflammatory, degenerative, or non-neurological disease. No steroid concentration differences were found among diagnoses. Dehydroepiandrosterone and dehydroepiandrosterone-sulfate concentrations were higher in males than in females and dehydroepiandrosterone-sulfate decreased with increasing age. No sex or age effects were observed on cortisol or hormone ratios. Although limited to a relatively small sample, our results show sex- and age-dependent variations in these neurosteroid concentrations in cerebrospinal fluid. The role of such variations in the pathophysiology of the dog brain warrants further investigation.
