Advances in innate immune evasion strategies of enterovirus 71

VernacularTitle:EV71病毒固有免疫逃逸机制的研究进展
Author: Yuanmin DONG ¹ ; Nan LU ; Cai ZHANG
Author Information

1. 山东大学药学院免疫药物学研究所，济南　250012
Keywords: EV71; Interferon; Innate immune escape; Anti-EV71 drugs
From: Chinese Journal of Microbiology and Immunology 2021;41(6):493-500
CountryChina
Language:Chinese
Abstract: Enterovirus 71 (EV71) is one of the main pathogens causing hand, foot and mouth disease (HFMD), which seriously threatens the health of infants and young children and causes major infectious diseases in the Asia-Pacific region. The host′s innate immune response is the most effective way to fight against viral infections. However, EV71 has evolved a series of strategies, escaping from innate immune surveillance and destroying its antiviral function in the process of gaming with the host. This article mainly focuses on the research progress of EV71′s innate immune escape mechanism, and provides help for the development of anti-EV71 infection drugs.