Research progress in antifungal resistance mechanisms in Candida auris

VernacularTitle:耳念珠菌耐药机制的研究进展
Author: Danrui JING ¹ ; Xiaofang LI ; Weida LIU
Author Information

1. 中国医学科学院北京协和医学院皮肤病研究所真菌科，南京　210042
Keywords: Candida auris; Antifungal resistance; Research progress
From: Chinese Journal of Microbiology and Immunology 2021;41(6):484-487
CountryChina
Language:Chinese
Abstract: Candida auris ( C. auris) is a recently emerged multidrug-resistant fungal pathogen, featured by difficulty in identification, high mortality and easy spread in hospital environments. Furthermore, C. auris is resistant to various frontline antifungals. However, the mechanisms governing drug resistance remain unclear. This review summarized the mechanisms of triazole resistance in C. auris, including ERG11 missense mutations or overexpression, the activity of efflux pumps, missense mutations in TAC1 B, the gain of an extra copy of chromosomeⅤ, the role of Hsp90 and biofilm formation. In addition, the factors associated with the resistance to other drugs including echinocandins, polyenes, nucleoside analogues and acrylamide were also reviewed.